Theresa May's Brexit withdrawal plan has been defeated by a record margin of 230 votes in the House of Commons.
Around 1 in 3 of her own Conservative MPs voted against it.
Labour has now launched a no-confidence vote in the government which will take place later today.
French President Emmanuel Macron says Britain would be the 'biggest loser' if it leaves the European Union without a deal.
But how did MPs from across the political spectrum vote in the South West?
BRISTOL AND NORTH SOMERSET
Bristol North West - Darren Jones (Labour) - AGAINST
Bristol South - Karin Smyth (Labour) - AGAINST
Bristol West - Thangam Debbonaire (Labour) - AGAINST
Bristol East - Kerry McCarthy (Labour) - AGAINST
Blimey. Lost by 230. That’s massive.— Kerry McCarthy (@KerryMP) January 15, 2019
Filton and Bradley Stoke - Jack Lopresti (Conservative) - FOR
Kingswood - Chris Skidmore (Conservative) - FOR
Weston-super-Mare - John Penrose (Conservative) - FOR
North Somerset - Dr Liam Fox (Conservative) - FOR
Thornbury and Yate - Luke Hall (Conservative) - FOR
BATH AND WEST WILTSHIRE
Bath - Wera Hobhouse (Lib Dem) - AGAINST
What a massive margin to defeat #brexit deal. What next for government— Wera Hobhouse MP (@Wera_Hobhouse) January 15, 2019
North East Somerset - Jacob Rees-Mogg (Conservative) - AGAINST
Somerton and Frome - David Warburton (Conservative) - FOR
Devizes - Claire Perry (Conservative) - FOR
Chippenham - Michelle Donelan (Conservative) - FOR
Cheltenham - Alex Chalk (Conservative - FOR
We have now arrived at a point that in my view we should have reached some time ago - a policy of working across political parties to achieve a solution that Parl can agree on.— Alex Chalk (@AlexChalkChelt) January 15, 2019
Gloucester - Richard Graham (Conservative) - FOR
Tewkesbury - Laurence Robertson (Conservative) - AGAINST
Torbay MP Kevin Foster received nearly 1,000 letters and emails about the draft Withdrawal Agreement ahead of last night's vote.
He said: "These ranged from residents going into detail about their views in personal letters to emails via campaign websites which allow residents to select an option, then send me an email.
"The views expressed include the full spectrum of options from Revoking Article 50 to leaving without a withdrawal agreement and trading on World Trade Organisation Terms. In short it is impossible for me to agree with every view expressed."
Click play to hear Kevin Foster speaking after last night's vote
The MP for Newton Abbot Anne-Marie Morris last night voted against the deal believing it didn't go far enough
The MP for Totnes also voted against the deal, with doctor Sarah Wollaston calling for a second referendum instead.
Bridgwater and West Somerset - Ian Liddell-Grainger (Con) - AGAINST
Taunton Deane - Rebecca Pow (Con) - FOR
Wells - James Heappey (Con) - FOR
Yeovil - Marcus Fysh (Con) - AGAINST
Somerton and Frome - David Warburton (Con) - FOR
The MP for Wells James Heappey admits the situation is a mess, but says tonight he will vote to support the PM and her plan to start cross-party talks to salvage a workable Brexit deal.
He said: "She has the ability to seeks a consensus and I think if the Commons are sensible they will recognise that the British public are pretty desperate for us to make some progress.
"They are not looking on, cheering us on saying 'go on, isn't it brilliant that Parliament is trying itself in knots and we're in a state of complete paralysis'."
Click play to hear Wells MP James Heappey
Yeovil MP Marcus Fysh, who voted against the Prime Minister last night,. said: "It was obviously a very resounding defeat for the withdrawal agreement but that gives a perfect opportunity now.
"A mandate for the Prime Minister to go back to the EU and say look this really cannot pass Parliament.
"We have set out an alternative plan to go back to what they offered in March last year which was a free trade agreement for the whole of the UK."
Click play to hear Yeovil MP Marcus Fysh
North Dorset - Simon Hoare (Con) - FOR
West Dorset - Oliver Letwin (Con) - FOR
Disappointed but not surprised by the vote. Delivery of Brexit has to be in question and I welcome the approach @theresa_may has taken. A new chapter begins. Now time for Parliament to deliver collectively— Simon Hoare MP (@Simon4NDorset) January 15, 2019
Swindon North - Justin Tomlinson (Conservative) - FOR
Major blow tonight. Very real chance opposition MPs will wreck Brexit. Calm heads needed as the PM seeks to secure a majority to deliver an orderly, pragmatic Brexit. Parliament shouldnt ignore the democratic will of the British public, we have a duty to sort this ☑ #BrexitVote— Justin Tomlinson MP (@JustinTomlinson) January 15, 2019
Swindon South - Robert Buckland QC (Conservative) - FOR