Volunteers in Bristol are being offered up to £625 to test a potential Covid-19 vaccine.
Academics are leading the first human trials in Britain this week.
They're looking for more than 500 people - aged between 18 and 55 - to take part in tests in Bristol, London and Southampton.
Those taking part in the Bristol trial must not have been diagnosed with Covid-19 before, be pregnant or intending to become pregnant and must live in the BS1-6 and BS8 postcode areas.
Professors Andrew Pollard, Sarah Gilbert and Adrian Hill issued a joint statement last night after the Government announced the go-ahead for the trials saying: "The Oxford Covid vaccine team are delighted with Tuesday’s announcement by the Secretary of State for Health of funding for the evaluation of the new COVID19 vaccine.
"This week we will start the process of vaccine evaluation in our first human studies and are currently focussing all efforts on preparing for the start of the trials.
"Although it seems like a very long time since the work started, in reality it is less than four months since we first heard of an outbreak of severe pneumonia cases, and began to plan a response.
"Our brilliant team has been working tirelessly to get to this point using our skills and experience in vaccine development and testing, and will do the best job possible in moving quickly whilst at all times prioritising the safety of the trial participants."
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It comes as pre-planned Covid 19 tests for critical key staff are increasing in the region.
Testing sites are now operating in places like Bridgwater, Yeovil, Minehead and Exeter, as well as Bristol and Exeter airports.
We're told hundreds of people with pre-booked appointments have already used them.